Correlation of sperm DNA damage with blastocyst formation: systematic review and meta-analysis

Abstract Background The routine semen analysis fails to detect sperm DNA damage which contributes the majority of male factor infertility. Sperm fragmentation test (DFI) measures damage. Blastocyst formation is an important step in IVF ± ICSI. At present, literature lacks any data that correlates DFI and blastocyst formation. Main body abstract We searched MEDLINE other databases till 2020 for studies reported on assisted reproductive technology (ART). outcomes analyzed were (1) a comparison blastulation rates high low groups. (2) Comparison groups based (a) different assays (COMET, SCD, SCSA, TUNEL), (b) types ART (IVF/IVF + ICSI/ICSI). 10 included this review. A non-significant increase was observed group (OR = 0.70; 95% CI 0.4 1.21; P 0.20) with SCD TUNEL assays. Short conclusion Our study emphasizes (sperm damage) as marker results meta-analysis suggest may not adversely affect